View Program - 63rd Annual Drosophila Research Conference

During growth and development, tissue dynamics, such as tissue folding, cell intercalations and oriented cell divisions, are critical for shaping tissues and organs. However, less is known about how tissues regulate their dynamics during tissue homeostasis and repair, to maintain their shape after development and upon wounding. In this talk we will discuss how tissues respond to mechanical perturbations, such as stretching or wounding, by altering their actomyosin contractile structures, to change tissue dynamics and cell shape, and thus preserve tissue shape and patterning. We will present new data on how changes in the 3D shape of cells upon wounding promotes efficient wound repair. We combine genetics, biophysics and computational modelling to study these processes.

Coping with mechanical stress: tissue dynamics in homeostasis and repair