770A Poster - 12. Physiology, metabolism and aging
Thursday April 07, 2:00 PM - 4:00 PM

Authors:
Ji-Hyeon Lee; Hye-Yeon Lee; Subeen Shin; Kyung-Jin Min

Affiliation: Department of Biological Sciences and Bioengineering, Inha University, Incheon, Republic of Korea

Keywords:
i. lifespan; m. microbiome

Aronia berry (Aronia melanocarpa) is rich in polyphenolic compounds with various physiological and pharmacological activities. Several biologically active substances such as flavonoids and phenolic acids, have been reported to increase the lifespan of model organisms. With the increasing interest in the study of gut microbiota, it has been found that gut microbiota plays an important role in host health and aging. Recent studies have shown that the gut microbiota composition is changed by environmental factors like diet and aronia berry can modulate the gut microbial flora and lead to maintain a healthy/balanced gut microbiota. Although many studies have shown that aronia berry has anti-aging and prebiotic effect, the relationship between commensal microbes and the anti-aging effect of aronia berry is not illustrated yet. To test whether the anti-aging effect of aronia berry is related with commensal microbes, we generated axenic flies and measured their lifespan with or without aronia berry supplementation. In addition, 454-pyrosequencing analysis of the 16S rRNA gene was performed to investigate the microbial flora alteration in flies. Our results will provide the fundamental knowledge to address the relationship between commensal microbes and anti-aging effect of aronia berry.