167V Poster Online - Virtual Posters
Tuesday June 07, 11:00 AM - 3:00 PM

Authors:
Eriko Sasaki ^1,2; Magnus Nordborg ²

Affiliations:
1) Kyushu University; 2) Gregor Mendel Institute of Molecular Plant Biology

Keywords:
Comparative genomics & genome evolution

The epigenome, in a particular variation of DNA methylation profiles across individuals, has long been of interest as a modifier of the genetic code, with “mutations” reflecting past environments, stochastic events, or genetic regulation. To address this issue, we dissected an inherited epigenetics mark, mCHG methylation, using conditional GWAS approaches in Arabidopsis thaliana. Our study revealed the genome-wide mCHG levels largely share the variation with de novo methylation and are under the control of major trans-modifiers, including the key regulators CMT2, CMT3, MIR823A, and a novel regulator JMJ26 that specifically regulated RdDM-targeted TEs. These trans-modifiers could affect natural variation of transposon activity via interacting with a previously identified modifier of de novo methylation.