325V Poster Online - Virtual Posters
Tuesday June 07, 11:00 AM - 3:00 PM

Authors:
Diego F. Salazar-Tortosa ^1,2; Yi-Fei Huang ^3,4; David Enard ¹

Affiliations:
1) Department of Ecology and Evolutionary Biology, University of Arizona, Tucson, AZ, USA.; 2) PROFITH ‘PROmoting FITness and Health through physical activity’ research group, Sport and Health University Research Institute (iMUDS), University of Granada, Granada, Spain; 3) Department of Biology, Pennsylvania State University, University Park, PA, USA.; 4) Huck Institutes of the Life Sciences, Pennsylvania State University, University Park, PA, USA.

Keywords:
Natural selection

How much genome differences between species reflect neutral or adaptive evolution is a central question in evolutionary genomics. In humans and other mammals, the prevalence of adaptive versus neutral genomic evolution has proven particularly difficult to quantify. The difficulty notably stems from the highly heterogenous organization of mammalian genomes at multiple levels (functional sequence density, recombination, etc.) that complicates the interpretation and distinction of adaptive vs. neutral evolution signals. Here, we introduce Mixture Density Regressions (MDRs) for the study of the determinants of recent adaptation in the human genome. MDRs provide a flexible regression model based on multiple Gaussian distributions. We use MDRs to model the association between recent selection signals and multiple genomic factors likely to affect positive selection, if the latter was common enough in the first place to generate these associations. We find that a MDR model with two Gaussian distributions provides an excellent fit to the genome-wide distribution of a common sweep summary statistic (iHS), with one of the two distributions likely capturing the positively selected component of the genome. We further find several factors associated with recent adaptation, including the recombination rate, the density of regulatory elements in immune cells and testis, GC-content, gene expression in immune cells, the density of mammal-wide conserved elements, and the distance to the nearest virus-interacting gene. These results support that strong positive selection was relatively common in recent human evolution and highlight MDRs as a powerful tool to make sense of signals of recent genomic adaptation.